1. GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling. Chai, P., Kheiri, S., Kuo, A., Shah, J., Kageler, L., Ge, R., … & Flynn, R. A. (2026). Nature, 1-11.
2. Radiation-guided nanoparticles enhance the efficacy of PARP inhibitors in primary and metastatic BRCA1-deficient tumors via immunotherapy. Khoury, R., Longobardi, G., Barnatan, T. T., Venkert, D., Alvarado, A. G., Yona, A., … & Satchi-Fainaro, R. (2025). Journal of Controlled Release, 383, 113812
3. The FKBPL-based therapeutic peptide, AD-01, protects the endothelium from hypoxia-induced damage by stabilising hypoxia inducible factor-α and inflammation. Ghorbanpour, S., Cartland, S. P., Chen, H., Seth, S., Ecker, R. C., Richards, C., … & McClements, L. (2025). Journal of Translational Medicine, 23(1), 309
4. Vascularized and perfusable human Heart‐on‐a‐Chip model recapitulates aspects of myocardial ischemia and enables analysis of nanomedicine delivery. Kim, J., Zhang, X., Wang, R., Najer, A., Lau, Q. Y., Cammack‐Najera, A., … & Stevens, M. M. (2025). . Advanced Materials, e18909
5. Engineering polystyrene microtube-embedded composite hydrogels for tunable vascular morphogenesis. Li, X., Khan, S., Wang, L., Chen, Y., Fang, X., Zhou, Y., & Wang, Y. (2025). Biomedical Materials
6. Retina-on-chip: engineering functional in vitro models of the human retina using organ-on-chip technologyThe 3D organ-on-a-chip model unveils a dual role of GDF-15 in vascular growth. Oosten, E. M., & ávan der Meer, A. D. (2025). Lab on a Chip
7. Patient-specific vascularized tumor model: Blocking monocyte recruitment with multispecific antibodies targeting CCR2 and CSF-1R. Nguyen, H. T., Kan, E. L., Humayun, M., Gurvich, N., Offeddu, G. S., Wan, Z., … & Kamm, R. D. (2025). Biomaterials, 312, 122731
8. Pericytes Promote More Vascularization than Stromal Cells via an Interleukin‐6‐Dependent Mechanism in Microfluidic Chips. Gonzalez‐Rubio, J., Kubiza, H., Xu, Y., Koenigs‐Werner, H., Schmitz, M. S., Schedel, M., … & Thiebes, A. L. (2025). Advanced Science, 2408131
9. iPSC-derived mesenchymal stromal cells stimulate neovascularization less than their primary counterparts. Gonzalez-Rubio, J., Zeevaert, K., Buhl, E. M., Schedel, M., Jockenhoevel, S., Cornelissen, C. G., … & Thiebes, A. L. (2025). Life Sciences, 361, 123298
10. A streamlined method to generate endothelial cells from human pluripotent stem cells via transient doxycycline-inducible ETV2 activation. Luo, A. C., Wang, J., Wang, K., Zhu, Y., Gong, L., Lee, U., … & Melero-Martin, J. M. (2024).  Angiogenesis, 27(4), 779-795.  10.1007/s10456-024-09937-5
11. Neovascularization directed by CAVIN1/CCBE1/VEGFC confers TMZ-resistance in glioblastoma. Wang, M., Xia, D., Xu, D., Yin, Y., Xu, F., Zhang, B., … & Zou, J. (2024). Cancer Letters, 582, 216593. 10.1016/j.canlet.2023.216593
12. The 3D organ-on-a-chip model unveils a dual role of GDF-15 in vascular growth. Sarad, K., Dulak, J., & Jaźwa-Kusior, A. (2024). Biochemical and Biophysical Research Communications, 733, 150441. 10.1016/j.bbrc.2024.150441
13. A placenta-on-a-chip model to determine the regulation of FKBPL and galectin-3 in preeclampsia. Ghorbanpour, S. M., Richards, C., Pienaar, D., Sesperez, K., Aboulkheyr Es, H., Nikolic, V. N., … & McClements, L. (2023). Cellular and Molecular Life Sciences, 80(2), 44. 10.1007/s00018-022-04648-w
14. Injectable extracellular matrix hydrogels contribute to native cell infiltration in a rat partial nephrectomy model. Kushige, H., Amano, Y., Yagi, H., Morisaku, T., Kojima, H., Satou, A., … & Kitagawa, Y. (2023). Journal of Biomedical Materials Research Part B: Applied Biomaterials, 111(1), 184-193. 10.1002/jbm.b.35144
15. Molecular, Cellular, and Functional Heterogeneity of Retinal and Choroidal Endothelial Cells. Kim, S. J., Lim, J. S., Park, J. H., & Lee, J. (2023). Investigative Ophthalmology & Visual Science, 64(10), 35-35.  10.1167/iovs.64.10.35
16. Sox17 mediates adult arterial endothelial cell adaptation to hemodynamics. Kim, D., Grath, A., Lu, Y. W., Chung, K., Winkelman, M., Schwarz, J. J., & Dai, G. (2023). Biomaterials, 293, 121946. 10.1016/j.biomaterials.2022.121946
17. 3D Microvascularized Tissue Models by Laser-Based Cavitation Molding of Collagen. Enrico, A., Voulgaris, D., Östmans, R., Sundaravadivel, N., Moutaux, L., Cordier, A., … & Stemme, G. (2022). Advanced Materials, 34(11), 2109823. 10.1002/adma.202109823
18. Isolinderalactone inhibits glioblastoma cell supernatant-induced angiogenesis. Lee, S. Y., Park, J. H., Cho, K. H., Kim, H., & Shin, H. K. (2022). Oncology Letters, 24(4), 1-9.  10.3892/ol.2022.13448
19. Podoplanin is Responsible for the Distinct Blood and Lymphatic Capillaries. Jeong, D. P., Hall, E., Neu, E., & Hanjaya-Putra, D. (2022).  Cellular and molecular bioengineering, 15(5), 467-478. 10.1007/s12195-022-00730-2
20. Sema4D-plexin-B1 signaling in recruiting dental stem cells for vascular stabilization on a microfluidic platform. Zhang, L., Han, Y., Chen, Q., & Dissanayaka, W. L. (2022).  Lab on a Chip, 22(23), 4632-4644.  10.1039/D2LC00632D
21. Timely Wound Healing Is Dependent on Endothelial but Not on Hair Follicle Stem Cell Toll-Like Receptor 2 Signaling. Xiong, L., McCoy, M., Murtazina, R., Podrez, E. A., & Byzova, T. V. (2022). Journal of Investigative Dermatology, 142(11), 3082-3092.  10.1016/j.jid.2022.04.018
22. Angiogenic Sprouting Dynamics Mediated by Endothelial-Fibroblast Interactions in Microfluidic Systems. Walji, N., Kheiri, S., & Young, E. W. (2021). Advanced Biology, 5(11), 2101080. 10.1002/adbi.202101080
23. Crumbs proteins regulate layered retinal vascular development required for vision. Son, S., Cho, M., & Lee, J. (2020).  Biochemical and Biophysical Research Communications, 521(4), 939-946. 10.1016/j.bbrc.2019.11.013
24. Isolinderalactone suppresses human glioblastoma growth and angiogenic activity in 3D microfluidic chip and in vivo mouse models. Park, J. H., Kim, M. J., Kim, W. J., Kwon, K. D., Ha, K. T., Choi, B. T., … & Shin, H. K. (2020). Cancer letters, 478, 71-81. 10.1016/j.canlet.2020.03.009
25. Microvessel Network Formation and Interactions with Pancreatic Islets in Three-Dimensional Chip Cultures. Rambøl, M. H., Han, E., & Niklason, L. E. (2020).Tissue Engineering Part A, 26(9-10), 556-568. 10.1089/ten.tea.2019.0186

1. Patient-specific vascularized tumor model: Blocking monocyte recruitment with multispecific antibodies targeting CCR2 and CSF-1R. Nguyen, H. T., Kan, E. L., Humayun, M., Gurvich, N., Offeddu, G. S., Wan, Z., … & Kamm, R. D. (2025). Biomaterials, 312, 122731
2. A placenta-on-a-chip model to determine the regulation of FKBPL and galectin-3 in preeclampsia. Ghorbanpour, S. M., Richards, C., Pienaar, D., Sesperez, K., Aboulkheyr Es, H., Nikolic, V. N., … & McClements, L. (2023).  Cellular and Molecular Life Sciences, 80(2), 44. 10.1007/s00018-022-04648-w
3. Exosomal miR-184 in the aqueous humor of patients with central serous chorioretinopathy: a potential diagnostic and prognostic biomarker. Yang, J. M., Kim, S. J., Park, S., Son, W., Kim, A., & Lee, J. (2023). Journal of Nanobiotechnology, 21(1), 242. 10.1186/s12951-023-02019-6
4. Antiangiogenic Nanomicelles for the Topical Delivery of Aflibercept to Treat Retinal Neovascular Disease. Zhao, X., Seah, I., Xue, K., Wong, W., Tan, Q. S. W., Ma, X., … & Loh, X. J. (2022). Advanced Materials, 34(25), 2108360.  10.1002/adma.202108360
5. Isolinderalactone inhibits glioblastoma cell supernatant induced angiogenesis. Lee, S. Y., Park, J. H., Cho, K. H., Kim, H., & Shin, H. K. (2022).  Oncology Letters, 24(4), 1-9.  10.3892/ol.2022.13448
6. Isolinderalactone suppresses human glioblastoma growth and angiogenic activity in 3D microfluidic chip and in vivo mouse models Park, J. H., Kim, M. J., Kim, W. J., Kwon, K. D., Ha, K. T., Choi, B. T., … & Shin, H. K. (2020). Cancer letters, 478, 71-81.  10.1016/j.canlet.2020.03.009
7. Phthalimide Derivative Shows Anti-angiogenic Activity in a 3D Microfluidic Model and No Teratogenicity in Zebrafish Embryos. Mercurio, A., Sharples, L., Corbo, F., Franchini, C., Vacca, A., Catalano, A., … & Adriani, G. (2019).  Frontiers in pharmacology, 10, 349.  10.3389/fphar.2019.00349
8. Quantitative screening of the effects of hyper-osmotic stress on cancer cells cultured in 2- or 3-dimensional settings. Miermont, A., Lee, S. W. L., Adriani, G., & Kamm, R. D. (2019). Scientific reports, 9(1), 13782. https://www.nature.com/articles/s41598-019-50198-w 10.1038/s41598-019-50198-w

1. The Interplay of M1 Macrophages and Dental Pulp Stem Cells Promotes Angiogenesis Through IL ‐8‐Dependent VEGF Regulation: An In Vitro Study. Thalakiriyawa, D. S., Koohi‐Moghadam, M., Hu, M., Wang, H., McGrath, C., & Dissanayaka, W. L. (2026). International Endodontic Journal, iej.70198.
2. DPSCs-generated contraction force regulates vessel network morphogenesis via YAP1/TGF-β1/Smad2 signaling. Chen, Y., Wang, W., Hu, M., Lin, S., Li, X., Wu, Z., Xu, J., & Zhang, C. (2026). Archives of Oral Biology, 188, 106623.
3. The FKBPL-based therapeutic peptide, AD-01, protects the endothelium from hypoxia-induced damage by stabilising hypoxia inducible factor-α and inflammation. Ghorbanpour, S., Cartland, S. P., Chen, H., Seth, S., Ecker, R. C., Richards, C., … & McClements, L. (2025). Journal of Translational Medicine, 23(1), 309
4. Semaphorin-4D signaling in recruiting dental stem cells for vascular stabilization. Zhang, L., Thalakiriyawa, D. S., Liu, J., Yang, S., Wang, Y., & Dissanayaka, W. L. (2025). Stem Cell Research & Therapy, 16(1), 25
5. Pericytes Promote More Vascularization than Stromal Cells via an Interleukin‐6‐Dependent Mechanism in Microfluidic Chips. Gonzalez‐Rubio, J., Kubiza, H., Xu, Y., Koenigs‐Werner, H., Schmitz, M. S., Schedel, M., … & Thiebes, A. L. (2025). Advanced Science, 2408131
6. iPSC-derived mesenchymal stromal cells stimulate neovascularization less than their primary counterparts. Gonzalez-Rubio, J., Zeevaert, K., Buhl, E. M., Schedel, M., Jockenhoevel, S., Cornelissen, C. G., … & Thiebes, A. L. (2025). Life Sciences, 361, 123298
7. Design and Discovery of New Collagen V-Derived FGF2-Blocking Natural Peptides Inhibiting Lung Squamous Cell Carcinoma In Vitro and In Vivo. Kuang, K., Chen, X., Wang, M., Han, W., Qiu, X., Jin, T., … & Jia, T. (2024). Journal of Medicinal Chemistry, 67(15), 12660-12675. 10.1021/acs.jmedchem.4c00654
8. Generation and Characterization of hiPSC‐Derived Vascularized‐, Perfusable Cardiac Microtissues‐on‐Chip. Arslan, U., van den Hil, F. E., Mummery, C. L., & Orlova, V. (2024).  Current Protocols, 4(7), e1097. 10.1002/cpz1.1097
9. Modeling early pathophysiological phenotypes of diabetic retinopathy in a human inner blood-retinal barrier-on-a-chip. Maurissen, T. L., Spielmann, A. J., Schellenberg, G., Bickle, M., Vieira, J. R., Lai, S. Y., … & Ragelle, H. (2024).  Nature Communications, 15(1), 1372.  10.1038/s41467-024-45456-z
10. Self-assembling 3D vessel-on-chip model with hiPSC-derived astrocytes. Nahon, D. M., Cuenca, M. V., van den Hil, F. E., Hu, M., de Korte, T., Frimat, J. P., … & Orlova, V. V. (2024).  Stem Cell Reports.  10.1016/j.stemcr.2024.05.006
11. Direct differentiation of human pluripotent stem cells into vascular network along with supporting mural cells. Bertucci, T., Kakarla, S., Winkelman, M. A., Lane, K., Stevens, K., Lotz, S., … & Dai, G. (2023). APL bioengineering, 7(3). 10.1063/5.0155207
12. Vascularized hiPSC-derived 3D cardiac microtissue on chip. Arslan, U., Brescia, M., Meraviglia, V., Nahon, D. M., van Helden, R. W., Stein, J. M., … & Orlova, V. V. (2023).  Stem cell reports, 18(7), 1394-1404 10.1016/j.stemcr.2023.06.001
13. A Facile Method for Generating a Smooth and Tubular Vessel Lumen Using a Viscous Fingering Pattern in a Microfluidic Device. Tu, T. Y., Shen, Y. P., Lim, S. H., & Wang, Y. K. (2022).  Frontiers in Bioengineering and Biotechnology, 10, 877480. 10.3389/fbioe.2022.877480
14. A Robust Method for Perfusable Microvascular Network Formation In Vitro Wan, Z., Zhong, A. X., Zhang, S., Pavlou, G., Coughlin, M. F., Shelton, S. E., … & Kamm, R. D. (2022). Small Methods, 6(6), 2200143. 10.1002/smtd.202200143
15. Physiologic flow-conditioning limits vascular dysfunction in engineered human capillaries. Haase, K., Piatti, F., Marcano, M., Shin, Y., Visone, R., Redaelli, A., … & Kamm, R. D. (2022).  Biomaterials, 280, 121248. 10.1016/j.biomaterials.2021.121248
16. Vascular defects associated with hereditary hemorrhagic telangiectasia revealed in patient-derived isogenic iPSCs in 3D vessels on chip. Orlova, V. V., Nahon, D. M., Cochrane, A., Cao, X., Freund, C., van den Hil, F., … & Mummery, C. L. (2022).  Stem Cell Reports, 17(7), 1536-1545. 10.1016/j.stemcr.2022.05.022
17. Vasculogenic Potency of Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells Results in Differing Vascular Network Phenotypes in a Microfluidic Chip. Mykuliak, A., Yrjänäinen, A., Mäki, A. J., Gebraad, A., Lampela, E., Kääriäinen, M., … & Vuorenpää, H. (2022). Frontiers in Bioengineering and Biotechnology, 10, 764237.  10.3389/fbioe.2022.764237
18. A robust vasculogenic microfluidic model using human immortalized endothelial cells and Thy1 positive fibroblasts. Wan, Z., Zhang, S., Zhong, A. X., Shelton, S. E., Campisi, M., Sundararaman, S. K., … & Kamm, R. D. (2021). Biomaterials, 276, 121032.  10.1016/j.biomaterials.2021.121032
19. Engineered 3D vessel-on-chip using hiPSC-derived endothelial- and vascular smooth muscle cells. Cuenca, M. V., Cochrane, A., van den Hil, F. E., de Vries, A. A., Oberstein, S. A. L., Mummery, C. L., & Orlova, V. V. (2021). Stem cell reports, 16(9), 2159-2168.  10.1016/j.stemcr.2021.08.003
20. Generation of Functional Vascular Endothelial Cells and Pericytes from Keratinocyte Derived Human Induced Pluripotent Stem Cells. Pars, S., Achberger, K., Kleger, A., Liebau, S., & Pashkovskaia, N. (2021). Cells, 10(1), 74. 10.3390/cells10010074
21. The effects of luminal and trans-endothelial fluid flows on the extravasation and tissue invasion of tumor cells in a 3D in vitro microvascular platform. Hajal, C., Ibrahim, L., Serrano, J. C., Offeddu, G. S., & Kamm, R. D. (2021).  Biomaterials, 265, 120470. 10.1016/j.biomaterials.2020.120470
22. Differential functional roles of fibroblasts and pericytes in the formation of tissue-engineered microvascular networks in vitro. Kosyakova, N., Kao, D. D., Figetakis, M., López-Giráldez, F., Spindler, S., Graham, M., … & Chang, W. G. (2020). NPJ Regenerative medicine, 5(1), 1. 10.1038/s41536-019-0086-3
23. Tumor-Derived cGAMP Regulates Activation of the Vasculature. Campisi, M., Sundararaman, S. K., Shelton, S. E., Knelson, E. H., Mahadevan, N. R., Yoshida, R., … & Barbie, D. A. (2020). Frontiers in Immunology, 11, 2090.  10.3389/fimmu.2020.02090
24. Tuning the local availability of VEGF within glycosaminoglycan‐based hydrogels to modulate vascular endothelial cell morphogenesis. Limasale, Y. D. P., Atallah, P., Werner, C., Freudenberg, U., & Zimmermann, R. (2020).  Advanced Functional Materials, 30(44), 2000068.  10.1002/adfm.202000068
25. Senescent Cells with Augmented Cytokine Production for Microvascular Bioengineering and Tissue Repairs. Xiao, Y., Liu, C., Chen, Z., Blatchley, M. R., Kim, D., Zhou, J., … & Fan, R. (2019). Advanced biosystems, 3(8), 1900089.  10.1002/adbi.201900089
26. On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics. Chen, M. B., Whisler, J. A., Fröse, J., Yu, C., Shin, Y., & Kamm, R. D. (2017).  Nature protocols, 12(5), 865-880.  10.1038/nprot.2017.018

1. Vascularized and perfusable human Heart‐on‐a‐Chip model recapitulates aspects of myocardial ischemia and enables analysis of nanomedicine delivery. Kim, J., Zhang, X., Wang, R., Najer, A., Lau, Q. Y., Cammack‐Najera, A., … & Stevens, M. M. (2025). . Advanced Materials, e18909
2. EMULSION human liver-on-a-chip for non-alcoholic steatohepatitis (NASH) drug testing. Balachander, G., Ng, I. C., Pai, R. R., Mitra, K., Tasnim, F., Lim, Y. S., … & Yu, H. (2025). Lab on a Chip
3. Retina-on-chip: engineering functional in vitro models of the human retina using organ-on-chip technologyThe 3D organ-on-a-chip model unveils a dual role of GDF-15 in vascular growth. Oosten, E. M., & ávan der Meer, A. D. (2025). Lab on a Chip
4. Shear-Stress Initiates Signal Two of NLRP3 Inflammasome Activation in LPS-Primed Macrophages through Piezo1. Fish, A., Forster III, J., Malik, V., & Kulkarni, A. (2025). ACS Applied Materials & Interfaces
5. A streamlined method to generate endothelial cells from human pluripotent stem cells via transient doxycycline-inducible ETV2 activation. Luo, A. C., Wang, J., Wang, K., Zhu, Y., Gong, L., Lee, U., … & Melero-Martin, J. M. (2024).  Angiogenesis, 27(4), 779-795.  10.1007/s10456-024-09937-5
6. Microheart: A microfluidic pump for functional vascular culture in microphysiological systems. Offeddu, G. S., Serrano, J. C., Chen, S. W., Shelton, S. E., Shin, Y., Floryan, M., & Kamm, R. D. (2021). Journal of biomechanics, 119, 110330.  10.1016/j.jbiomech.2021.110330

1. Retina-on-chip: engineering functional in vitro models of the human retina using organ-on-chip technologyThe 3D organ-on-a-chip model unveils a dual role of GDF-15 in vascular growth. Oosten, E. M., & ávan der Meer, A. D. (2025). Lab on a Chip
2. Pericytes Promote More Vascularization than Stromal Cells via an Interleukin‐6‐Dependent Mechanism in Microfluidic Chips. Gonzalez‐Rubio, J., Kubiza, H., Xu, Y., Koenigs‐Werner, H., Schmitz, M. S., Schedel, M., … & Thiebes, A. L. (2025). Advanced Science, 2408131
3. Assessing personalized responses to anti-PD-1 treatment using patient-derived lung tumor-on-chip. Veith, I., Nurmik, M., Mencattini, A., Damei, I., Lansche, C., Brosseau, S., … & Parrini, M. C. (2024). Cell Reports Medicine, 5(5) 10.1016/j.xcrm.2024.101549
4. Analysis of EMT induction in a non-invasive breast cancer cell line by mesenchymal stem cell supernatant: Study of 2D and 3D microfluidic based aggregate formation and migration ability, and cytoskeleton remodeling. Azadi, S., Torkashvand, E., Mohammadi, E., & Tafazzoli-Shadpour, M. (2023). Life Sciences, 320, 121545. 10.1016/j.lfs.2023.121545
5. Jagged1 intracellular domain/SMAD3 complex transcriptionally regulates TWIST1 to drive glioma invasion. Kim, J. Y., Hong, N., Park, S., Ham, S. W., Kim, E. J., Kim, S. O., … & Kim, H. (2023). Cell Death & Disease, 14(12), 822.  10.1038/s41419-023-06356-0
6. Ex vivo treatment in high grade serous ovarian cancer demonstrates the benefit of EZH2 inhibition in combination with standard therapy. Vo, H. V., Zeng, Q., Barbie, D. A., Gokhale, P. C., Adams, E., Paweletz, C. P., & Ivanova, E. (2022).  Cancer Research, 82(12_Supplement), 3264-3264. 1538-7445.AM2022-3264
7. Radiobiological effects of wound fluid on breast cancer cell lines and human-derived tumor spheroids in 2D and microfluidic culture. Jeibouei, S., Hojat, A., Mostafavi, E., Aref, A. R., Kalbasi, A., Niazi, V., … & Zali, H. (2022).  Scientific Reports, 12(1), 7668.  10.1038/s41598-022-11023-z
8. Evaluation of Tumor Response to Adjuvant Treatments using an Ex Vivo Culture of Breast Carcinoma Spheroids in a Microfluidic Device. Es, H. A., Aref, A. R., Granpayeh, L., Ebrahimi, M., & Baharvand, H. (2021). MedRxiv, 2021-05.  10.1101/2021.05.19.21257378
9. Pirfenidone Reduces Epithelial-Mesenchymal Transition and Spheroid Formation in Breast Carcinoma through Targeting Cancer-Associated Fibroblasts. (CAFs) Es, H. A., Cox, T. R., Sarafraz-Yazdi, E., Thiery, J. P., & Warkiani, M. E. (2021). Cancers, 13(20), 5118.  10.3390/cancers13205118
10. Rapid spheroid assays in a 3-dimensional cell culture chip. Teh, J. L., Abdul Rahman, S. F., Domnic, G., Satiyasilan, L., Chear, N. J. Y., Singh, D., & Mohana-Kumaran, N. (2021).  BMC research notes, 14, 1-6. 10.1186/s13104-021-05727-0
11. Stimuli-Responsive Nanodiamond-Based Biosensor for Enhanced Metastatic Tumor Site Detection. Wang, X., Gu, M., Toh, T. B., Abdullah, N. L. B., & Chow, E. K. H. (2018). Translating Life Sciences Innovation, 23(1), 44-56. 10.1177/2472630317735497

1. Ether lipids influence cancer cell fate by modulating iron uptake. Mansell, R. P., Müller, S., Yang, J. S., Innes-Gold, S., Das, S., Reinhardt, F., … & Henry, W. S. (2026). Nature Communications
2. Ablation of prostaglandin E2 signalling through dual receptor knockout in CAR T cells enhances therapeutic efficacy in solid tumours. Dörr, J., Gregor, L., Lacher, S. B., Oner, A., Sun, Y., Piseddu, I., … & Kobold, S. (2026).Nature Biomedical Engineering, 1-14
3. In vitro integration of a functional vasculature to model endothelial regulation of chemotherapy and T-cell immunotherapy in liver cancer. Vasudevan, J., Vijayakumar, R., Reales-Calderon, J. A., Lam, M. S., Ow, J. R., Aw, J., … & Pavesi, A. (2025). Biomaterials, 123175
4. A 3D pancreatic tumor model to study T cell infiltration. Mollica, H., Teo, Y. J., Tan, A. S. M., Tan, D. Z. M., Decuzzi, P., Pavesi, A., & Adriani, G. (2021).  Biomaterials Science, 9(22), 7420-7431.  10.1039/D1BM00210D
5. Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells. Ogino, T., Matsunaga, N., Tanaka, T., Tanihara, T., Terajima, H., Yoshitane, H., … & Ohdo, S. (2021).  Elife, 10, e66155. 10.7554/eLife.66155
6. The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination Offeddu, G. S., Hajal, C., Foley, C. R., Wan, Z., Ibrahim, L., Coughlin, M. F., & Kamm, R. D. (2021).Communications biology, 4(1), 255.  10.1038/s42003-021-01774-2
7. Characterizing the effect of substrate stiffness on the extravasation potential of breast cancer cells using a 3D microfluidic model. Azadi, S., Tafazzoli Shadpour, M., & Warkiani, M. E. (2021). Biotechnology and Bioengineering, 118(2), 823-835. 10.1002/bit.27612
8. Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model. Lee, S. W. L., Adriani, G., Ceccarello, E., Pavesi, A., Tan, A. T., Bertoletti, A., … & Wong, S. C. (2018). Frontiers in Immunology, 9, 416.  10.3389/fimmu.2018.00416

1. Ablation of prostaglandin E2 signalling through dual receptor knockout in CAR T cells enhances therapeutic efficacy in solid tumours. Dörr, J., Gregor, L., Lacher, S. B., Oner, A., Sun, Y., Piseddu, I., … & Kobold, S. (2026).Nature Biomedical Engineering, 1-14
2. Development of a Patient-Derived 3D Immuno-Oncology Platform to Potentiate Immunotherapy Responses in Ascites-Derived Circulating Tumor Cells. Gerton, T. J., Green, A., Campisi, M., Chen, M., Gjeci, I., Mahadevan, N., … & Dinulescu, D. M. (2023).  Cancers, 15(16), 4128. 10.3390/cancers15164128
3. Retina-on-chip: engineering functional in vitro models of the human retina using organ-on-chip technologyThe 3D organ-on-a-chip model unveils a dual role of GDF-15 in vascular growth. Oosten, E. M., & ávan der Meer, A. D. (2025). Lab on a Chip
4. Patient-specific vascularized tumor model: Blocking monocyte recruitment with multispecific antibodies targeting CCR2 and CSF-1R. Nguyen, H. T., Kan, E. L., Humayun, M., Gurvich, N., Offeddu, G. S., Wan, Z., … & Kamm, R. D. (2025). Biomaterials, 312, 122731
5. Pericytes Promote More Vascularization than Stromal Cells via an Interleukin‐6‐Dependent Mechanism in Microfluidic Chips. Gonzalez‐Rubio, J., Kubiza, H., Xu, Y., Koenigs‐Werner, H., Schmitz, M. S., Schedel, M., … & Thiebes, A. L. (2025). Advanced Science, 2408131
6. Endocrine Therapy Synergizes with SMAC Mimetics to Potentiate Antigen Presentation and Tumor Regression in Hormone Receptor-Positive Breast Cancer. Hermida-Prado, F., Xie, Y., Sherman, S., Nagy, Z., Russo, D., Akhshi, T., … & Jeselsohn, R. (2023). Cancer research, 83(19), 3284-3304. 10.1158/0008-5472.CAN-23-1711
7. Therapeutic targeting of tumor spheroids in a 3D microphysiological renal cell carcinoma-on-a-chip system. Miller, C. P., Fung, M., Jaeger-Ruckstuhl, C. A., Xu, Y., Warren, E. H., Akilesh, S., & Tykodi, S. S. (2023) Neoplasia, 46, 100948.  10.1016/j.neo.2023.100948
8. A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non–Small Cell Lung Cancer. Son, J., Jang, J., Beyett, T. S., Eum, Y., Haikala, H. M., Verano, A., … & Jänne, P. A. (2022). Cancer research, 82(8), 1633-1645.  10.1158/0008-5472.CAN-21-2693
9. Catulin reporter marks a heterogeneous population of invasive breast cancer cells with some demonstrating plasticity and participating in vascular mimicry. Gielata, M., Karpińska, K., Gwiazdowska, A., Boryń, Ł., & Kobielak, A. (2022). Scientific Reports, 12(1), 12673. 10.1038/s41598-022-16802-2
10. Oncogenic activity of glucocorticoid receptor β is controlled by ubiquitination-dependent interaction with USP49 in glioblastoma cells. Hu, Y., Jiang, Y., Zhang, Z., Wang, J., Zhang, B., Gong, L., … & Yin, Y. (2022). Molecular Cancer Research, 20(1), 92-101. 10.1158/1541-7786.MCR-20-1068
11. Radiobiological effects of wound fluid on breast cancer cell lines and human-derived tumor spheroids in 2D and microfluidic culture. Jeibouei, S., Hojat, A., Mostafavi, E., Aref, A. R., Kalbasi, A., Niazi, V., … & Zali, H. (2022). Scientific Reports, 12(1), 7668.  10.1038/s41598-022-11023-z
12. Thermal stress involved in TRPV2 promotes tumorigenesis through the pathways of HSP70/27 and PI3K/Akt/mTOR in esophageal squamous cell carcinoma. Huang, R., Li, S., Tian, C., Zhou, P., Zhao, H., Xie, W., … & Li, Z. (2022). British Journal of Cancer, 127(8), 1424-1439. 10.1038/s41416-022-01896-2
13. A 3D pancreatic tumor model to study T cell infiltration. Mollica, H., Teo, Y. J., Tan, A. S. M., Tan, D. Z. M., Decuzzi, P., Pavesi, A., & Adriani, G. (2021).  Biomaterials Science, 9(22), 7420-7431. 10.1039/D1BM00210D
14. Apoptosis mapping in space and time of 3D tumor ecosystems reveals transmissibility of cytotoxic cancer death. Veith, I., Mencattini, A., Picant, V., Serra, M., Leclerc, M., Comes, M. C., … & Martinelli, E. (2021).  PLoS computational biology, 17(3), e1008870. 10.1371/journal.pcbi.1008870
15. Exosomal miR-193a and let-7g accelerate cancer progression on primary colorectal cancer and paired peritoneal metastatic cancer. Cho, W. C., Kim, M., Park, J. W., Jeong, S. Y., & Ku, J. L. (2021).  Translational oncology, 14(2), 101000. 10.1016/j.tranon.2020.101000
16. Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity. Mahadevan, N. R., Knelson, E. H., Wolff, J. O., Vajdi, A., Saigí, M., Campisi, M., … & Barbie, D. A. (2021).Cancer discovery, 11(8), 1952-1969.  10.1158/2159-8290.CD-20-0913
17. Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion. Harada, A., Matsumoto, S., Yasumizu, Y., Shojima, K., Akama, T., Eguchi, H., & Kikuchi, A. (2021).  Elife, 10, e66721. 10.7554/eLife.66721
18. Pirfenidone Reduces EpithelialMesenchymal Transition and Spheroid Formation in Breast Carcinoma through Targeting Cancer-Associated Fibroblasts (CAFs). Es, H. A., Cox, T. R., Sarafraz-Yazdi, E., Thiery, J. P., & Warkiani, M. E. (2021). Cancers, 13(20), 5118.  10.3390/cancers13205118
19. The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination. Offeddu, G. S., Hajal, C., Foley, C. R., Wan, Z., Ibrahim, L., Coughlin, M. F., & Kamm, R. D. (2021). Communications biology, 4(1), 255.  10.1038/s42003-021-01774-2
20. Multidimensional hydrogel models reveal endothelial network angiocrine signals increase glioblastoma cell number, invasion, and temozolomide resistance. Ngo, M. T., Karvelis, E., & Harley, B. A. (2020). Integrative Biology, 12(6), 139-149.  10.1093/intbio/zyaa010
21. Nanodiamond-Mediated Delivery of a G9a Inhibitor for Hepatocellular Carcinoma Therapy. Gu, M., Toh, T. B., Hooi, L., Lim, J. J., Zhang, X., & Chow, E. K. H. (2019).  ACS applied materials & interfaces, 11(49), 45427-45441. 10.1021/acsami.9b16323
22. Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer. Kitajima, S., Ivanova, E., Guo, S., Yoshida, R., Campisi, M., Sundararaman, S. K., … & Barbie, D. A. (2019).  Cancer discovery, 9(1), 34-45.  10.1158/2159-8290.CD-18-0689
23. MBNL1 alternative splicing isoforms play opposing roles in cancer. Tabaglio, T., Low, D. H., Teo, W. K. L., Goy, P. A., Cywoniuk, P., Wollmann, H., … & Guccione, E. (2018). Life science alliance, 1(5). 10.26508/lsa.201800157
24. Macrophage-secreted TNFα and TGFβ1 influence migration speed and persistence of cancer cells in 3D tissue culture via independent pathways. Li, R., Hebert, J. D., Lee, T. A., Xing, H., Boussommier-Calleja, A., Hynes, R. O., … & Kamm, R. D. (2017).  Cancer research, 77(2), 279-290.  10.1158/0008-5472.CAN-16-0442

1. An Extracellular matrix-producing subset of cancer-associated fibroblasts drives chemoresistance in breast cancer via SRC activation and G0S2 upregulation. Hofer, I., Kieffer, Y., Mencattini, A., Croizer, H., Mhaidly, R., Descroix, S., … & Parrini, M. C. (2025). Cancer Research
2. E711-19 placement and orientation dictate CD8+ T cell response in structurally defined spherical nucleic acid vaccines. Hwang, J., Ocampo, T. A., Mayer, V., Kang, J., Paranandi, K. S., Kim, Y. J., … & Mirkin, C. A. (2026). Science Advances, 12(7), eaec3876
3. Ablation of prostaglandin E2 signalling through dual receptor knockout in CAR T cells enhances therapeutic efficacy in solid tumours. Dörr, J., Gregor, L., Lacher, S. B., Oner, A., Sun, Y., Piseddu, I., … & Kobold, S. (2026).Nature Biomedical Engineering, 1-14
4. Vascularized and perfusable human Heart‐on‐a‐Chip model recapitulates aspects of myocardial ischemia and enables analysis of nanomedicine delivery. Kim, J., Zhang, X., Wang, R., Najer, A., Lau, Q. Y., Cammack‐Najera, A., … & Stevens, M. M. (2025). . Advanced Materials, e18909
5. Overcoming resistance to immunotherapy by targeting CD38 in human tumor explants. Revach, O. Y., Cicerchia, A. M., Shorer, O., Palin, C. A., Petrova, B., Anderson, S., … & Jenkins, R. W. (2025). Cell Reports Medicine
6. EMULSION human liver-on-a-chip for non-alcoholic steatohepatitis (NASH) drug testing. Balachander, G., Ng, I. C., Pai, R. R., Mitra, K., Tasnim, F., Lim, Y. S., … & Yu, H. (2025). Lab on a Chip
7. In Vitro 3D Models of Haematological Malignancies: Current Trends and the Road Ahead? Mattioda, C., Voena, C., Ciardelli, G., & Mattu, C. (2025). Cells, 14(1), 38
8. TBK1 Targeting Is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids. Sun, Y., Maggs, L., Panda, A., Wright, S. J., Cicerchia, A. M., Jenney, A., … & Jenkins, R. W. (2025). Cancer Immunology Research, 13(2), 210-228
9. In vitro integration of a functional vasculature to model endothelial regulation of chemotherapy and T-cell immunotherapy in liver cancer. Vasudevan, J., Vijayakumar, R., Reales-Calderon, J. A., Lam, M. S., Ow, J. R., Aw, J., … & Pavesi, A. (2025). Biomaterials, 123175
10. RNA sensing induced by chromosome missegregation augments anti-tumor immunity. Sasaki, N., Homme, M., Murayama, T., Osaki, T., Tenma, T., An, T., … & Kitajima, S. (2025). Molecular cell, 85(4), 770-786
11. In Vitro 3D Models of Haematological Malignancies: Current Trends and the Road Ahead? Mattioda, C., Voena, C., Ciardelli, G., & Mattu, C. (2025). Cells, 14(1), 38
12. Pooled screening for CAR function identifies novel IL-13Rα2-targeted CARs for treatment of glioblastoma. Gordon, K. S., Perez, C. R., Garmilla, A., Lam, M. S., Aw, J. J., Datta, A., … & Birnbaum, M. E. (2025). Journal for Immunotherapy of Cancer, 13(1), e009574
13. Retina-on-chip: engineering functional in vitro models of the human retina using organ-on-chip technologyThe 3D organ-on-a-chip model unveils a dual role of GDF-15 in vascular growth. Oosten, E. M., & ávan der Meer, A. D. (2025). Lab on a Chip
14. Semaphorin-4D signaling in recruiting dental stem cells for vascular stabilization. Zhang, L., Thalakiriyawa, D. S., Liu, J., Yang, S., Wang, Y., & Dissanayaka, W. L. (2025). Stem Cell Research & Therapy, 16(1), 25
15. In Vitro 3D Models of Haematological Malignancies: Current Trends and the Road Ahead? Mattioda, C., Voena, C., Ciardelli, G., & Mattu, C. (2025). Cells, 14(1), 38
16. Patient-specific vascularized tumor model: Blocking monocyte recruitment with multispecific antibodies targeting CCR2 and CSF-1R. Nguyen, H. T., Kan, E. L., Humayun, M., Gurvich, N., Offeddu, G. S., Wan, Z., … & Kamm, R. D. (2025). Biomaterials, 312, 122731
17. Pericytes Promote More Vascularization than Stromal Cells via an Interleukin‐6‐Dependent Mechanism in Microfluidic Chips. Gonzalez‐Rubio, J., Kubiza, H., Xu, Y., Koenigs‐Werner, H., Schmitz, M. S., Schedel, M., … & Thiebes, A. L. (2025). Advanced Science, 2408131
18. 3D vascularized microphysiological system for investigation of tumor-endothelial crosstalk in anti-cancer drug resistance. Kim, S., Park, J., Ho, J. N., Kim, D., Lee, S., & Jeon, J. S. (2023). Biofabrication, 15(4), 045016. 10.1088/1758-5090/acef99
19. Cotargeting a MYC/eIF4A-survival axis improves the efficacy of KRAS inhibitors in lung cancer. Nardi, F., Perurena, N., Schade, A. E., Li, Z. H., Ngo, K., Ivanova, E. V., … & Cichowski, K. (2023).  The Journal of Clinical Investigation, 133(16). 10.1172/JCI167651
20. Histone-lysine N-methyltransferase EHMT2 (G9a) inhibition mitigates tumorigenicity in Myc-driven liver cancer. Thng, D. K. H., Hooi, L., Toh, C. C. M., Lim, J. J., Rajagopalan, D., Syariff, I. Q. C., … & Chow, E. K. H. (2023).  Molecular Oncology, 17(11), 2275-2294. 10.1002/1878-0261.13417
21. Reaching the Tumor: Mobility of Polymeric Micelles Inside an In Vitro Tumor-on-a-Chip Model with Dual ECM. Olea, A. R., Jurado, A., Slor, G., Tevet, S., Pujals, S., De La Rosa, V. R., … & Albertazzi, L. (2023). ACS applied materials & interfaces, 15(51), 59134-59144. 10.1021/acsami.3c12798
22. Ex vivo treatment in high grade serous ovarian cancer demonstrates the benefit of EZH2 inhibition in combination with standard therapy. Vo, H. V., Zeng, Q., Barbie, D. A., Gokhale, P. C., Adams, E., Paweletz, C. P., & Ivanova, E. (2022). Cancer Research, 82(12_Supplement), 3264-3264. 10.1158/1538-7445.AM2022-3264
23. Thermal stress involved in TRPV2 promotes tumorigenesis through the pathways of HSP70/27 and PI3K/Akt/mTOR in esophageal squamous cell carcinoma. Huang, R., Li, S., Tian, C., Zhou, P., Zhao, H., Xie, W., … & Li, Z. (2022). British Journal of Cancer, 127(8), 1424-1439. 10.1038/s41416-022-01896-2
24. 5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment. Yusefi, M., Lee-Kiun, M. S., Shameli, K., Teow, S. Y., Ali, R. R., Siew, K. K., … & Kuča, K. (2021).Carbohydrate Polymers, 273, 118523. 10.1016/j.carbpol.2021.118523
25. Effects of Wound Fluid on Breast Cancer-derived Spheroids in a 3D Culture System: A Case Series Study Hojat, A., Jeibouei, S., Aref, A. R., Kalbasi, A., Moghaddam, M., Mohammadi, F., … & Akbari, M. E. (2021). Iranian Journal of Pharmaceutical Research: IJPR, 21(1), e123828. 10.5812/ijpr.123828
26. Real-Time Ratiometric Imaging of Micelles Assembly State in a Microfluidic Cancer-on-a-Chip. Feiner-Gracia, N., Glinkowska Mares, A., Buzhor, M., Rodriguez-Trujillo, R., Samitier Marti, J., Amir, R. J., … & Albertazzi, L. (2020). ACS Applied Bio Materials, 4(1), 669-681. 10.1021/acsabm.0c01209
27. Use of Ex Vivo Patient-Derived Tumor Organotypic Spheroids to Identify Combination Therapies for HER2 Mutant Non–Small Cell Lung Cancer. Ivanova, E., Kuraguchi, M., Xu, M., Portell, A. J., Taus, L., Diala, I., … & Jänne, P. A. (2020).  Clinical Cancer Research, 26(10), 2393-2403. 10.1158/1078-0432.CCR-19-1844
28. Assessing Therapeutic Efficacy of MEK Inhibition in a KRASG12C-Driven Mouse Model of Lung Cancer. Li, S., Liu, S., Deng, J., Akbay, E. A., Hai, J., Ambrogio, C., … & Wong, K. K. (2018).  Clinical Cancer Research, 24(19), 4854-4864.  10.1158/1078-0432.CCR-17-3438

1. Ether lipids influence cancer cell fate by modulating iron uptake. Mansell, R. P., Müller, S., Yang, J. S., Innes-Gold, S., Das, S., Reinhardt, F., … & Henry, W. S. (2026). Nature Communications
2. Vascular STING activation facilitates NK cell anti-tumor immunity in small cell lung cancer. Campisi, M., Osaki, T., Dryg, I., Stornante, C., Wolff, J., Weirather, J., … & Mahadevan, N. R. (2026). Cancer Cell
3. Ablation of prostaglandin E2 signalling through dual receptor knockout in CAR T cells enhances therapeutic efficacy in solid tumours. Dörr, J., Gregor, L., Lacher, S. B., Oner, A., Sun, Y., Piseddu, I., … & Kobold, S. (2026).Nature Biomedical Engineering, 1-14
4. E711-19 placement and orientation dictate CD8+ T cell response in structurally defined spherical nucleic acid vaccines. Hwang, J., Ocampo, T. A., Mayer, V., Kang, J., Paranandi, K. S., Kim, Y. J., … & Mirkin, C. A. (2026). Science Advances, 12(7), eaec3876
5. The impact of targeting TRAF2 and NCK-interacting protein kinase (TNIK) on anti-tumor effect and tumor immune environment in c-MYC-high small cell lung cancer. Tanimoto, A., Ramkumar, K., Stewart, C. A., Zhang, B., Concannon, K., Cardnell, R. J., … Byers, L. A. (2025). Journal of Thoracic Oncology, S1556086425030667.
6. An Extracellular matrix-producing subset of cancer-associated fibroblasts drives chemoresistance in breast cancer via SRC activation and G0S2 upregulation. Hofer, I., Kieffer, Y., Mencattini, A., Croizer, H., Mhaidly, R., Descroix, S., … & Parrini, M. C. (2025). Cancer Research
7. An Extracellular Matrix-Producing Subset of Cancer-Associated Fibroblasts Drives Chemoresistance in Breast Cancer via SRC Activation and G0S2 Upregulation. Hofer, I., Kieffer, Y., Mencattini, A., Croizer, H., Mhaidly, R., Descroix, S., … & Parrini, M. C. (2025). Cancer Research
8. Overcoming resistance to immunotherapy by targeting CD38 in human tumor explants. Revach, O. Y., Cicerchia, A. M., Shorer, O., Palin, C. A., Petrova, B., Anderson, S., … & Jenkins, R. W. (2025). Cell Reports Medicine
9. Intratumor heterogeneity of EGFR expression mediates targeted therapy resistance and formation of drug tolerant microenvironment. Alsaed, B., Lin, L., Son, J., Li, J., Smolander, J., Lopez, T., … & Haikala, H. M. (2025). Nature Communications, 16(1), 28
10. TBK1 Targeting Is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids. Sun, Y., Maggs, L., Panda, A., Wright, S. J., Cicerchia, A. M., Jenney, A., … & Jenkins, R. W. (2025). Cancer Immunology Research, 13(2), 210-228
11. RNA sensing induced by chromosome missegregation augments anti-tumor immunity. Sasaki, N., Homme, M., Murayama, T., Osaki, T., Tenma, T., An, T., … & Kitajima, S. (2025). Molecular cell, 85(4), 770-786
12. Pooled screening for CAR function identifies novel IL-13Rα2-targeted CARs for treatment of glioblastoma. Gordon, K. S., Perez, C. R., Garmilla, A., Lam, M. S., Aw, J. J., Datta, A., … & Birnbaum, M. E. (2025). Journal for Immunotherapy of Cancer, 13(1), e009574
13. Retina-on-chip: engineering functional in vitro models of the human retina using organ-on-chip technologyThe 3D organ-on-a-chip model unveils a dual role of GDF-15 in vascular growth. Oosten, E. M., & ávan der Meer, A. D. (2025). Lab on a Chip
14. Patient-specific vascularized tumor model: Blocking monocyte recruitment with multispecific antibodies targeting CCR2 and CSF-1R. Nguyen, H. T., Kan, E. L., Humayun, M., Gurvich, N., Offeddu, G. S., Wan, Z., … & Kamm, R. D. (2025). Biomaterials, 312, 122731
15. Pericytes Promote More Vascularization than Stromal Cells via an Interleukin‐6‐Dependent Mechanism in Microfluidic Chips. Gonzalez‐Rubio, J., Kubiza, H., Xu, Y., Koenigs‐Werner, H., Schmitz, M. S., Schedel, M., … & Thiebes, A. L. (2025). Advanced Science, 2408131
16. Investigating size-dependent invasion behaviors and therapeutic responses of the 42MGBA glioblastoma spheroids. Fok, S., Ivanova, Y., Kriuchkovskaia, V., & Harley, B. (2024).  Cancer Research, 84(6_Supplement), 238-238. 10.1158/1538-7445.AM2024-238
17. CD19 CAR-expressing iPSC-derived NK cells effectively enhance migration and cytotoxicity into glioblastoma by targeting to the pericytes in tumor microenvironment. Kong, D., Kwon, D., Moon, B., Kim, D. H., Kim, M. J., Choi, J., & Kang, K. S. (2024). Biomedicine & Pharmacotherapy, 174, 116436. 10.1016/j.biopha.2024.116436
18. Microfluidic model of the alternative vasculature in neuroblastoma. Villasante, A., Lopez-Martinez, M. J., Quiñonero, G., Garcia-Lizarribar, A., Peng, X., & Samitier, J. (2024). In vitro models, 3(1), 49-63. 10.1007/s44164-023-00064-x
19. The OrganiX microfluidic system to recreate the complex tumour microenvironment. Adriani, G., & Pavesi, A. (2024). Nature Reviews Immunology, 24(5), 307-307.  10.1038/s41577-024-01011-x
20. YAP/TEAD involvement in resistance to paclitaxel chemotherapy in lung cancer. Brosseau, S., Abreu, P., Bouchez, C., Charon, L., Kieffer, Y., Gentric, G., … & Zalcman, G. (2024). Molecular and Cellular Biochemistry, 1-18. 10.1007/s11010-024-04949-7
21. Convergent Approaches to Delineate the Metabolic Regulation of Tumor Invasion by Hyaluronic Acid Biosynthesis. Shimpi, A. A., Tan, M. L., Vilkhovoy, M., Dai, D., Roberts, L. M., Kuo, J. C. H., … & Fischbach, C. (2023). Advanced Healthcare Materials, 12(14), 2202224. 10.1002/adhm.202202224
22. Development of a Patient-Derived 3D Immuno-Oncology Platform to Potentiate Immunotherapy Responses in Ascites-Derived Circulating Tumor Cells. Gerton, T. J., Green, A., Campisi, M., Chen, M., Gjeci, I., Mahadevan, N., … & Dinulescu, D. M. (2023).  Cancers, 15(16), 4128. 10.3390/cancers15164128
23. Priming a vascular-selective cytokine response permits CD8+ T-cell entry into tumors. Kim, D. J., Anandh, S., Null, J. L., Przanowski, P., Bhatnagar, S., Kumar, P., … & Dudley, A. C. (2023). Nature Communications, 14(1), 2122. 10.1038/s41467-023-37807-z
24. Therapeutic targeting of tumor spheroids in a 3D microphysiological renal cell carcinoma-on-a-chip system. Miller, C. P., Fung, M., Jaeger-Ruckstuhl, C. A., Xu, Y., Warren, E. H., Akilesh, S., & Tykodi, S. S. (2023).  Neoplasia, 46, 100948. 10.1016/j.neo.2023.100948
25. A 3D pancreatic tumor model to study T cell infiltration. Mollica, H., Teo, Y. J., Tan, A. S. M., Tan, D. Z. M., Decuzzi, P., Pavesi, A., & Adriani, G. (2021). Biomaterials Science, 9(22), 7420-7431. 10.1039/D1BM00210D
26. Apoptosis mapping in space and time of 3D tumor ecosystems reveals transmissibility of cytotoxic cancer death. Veith, I., Mencattini, A., Picant, V., Serra, M., Leclerc, M., Comes, M. C., … & Martinelli, E. (2021).PLoS computational biology, 17(3), e1008870. 10.1371/journal.pcbi.1008870
27. Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity. Mahadevan, N. R., Knelson, E. H., Wolff, J. O., Vajdi, A., Saigí, M., Campisi, M., … & Barbie, D. A. (2021). Cancer discovery, 11(8), 1952-1969.  10.1158/2159-8290.CD-20-0913
28. Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms. Hu, H., Piotrowska, Z., Hare, P. J., Chen, H., Mulvey, H. E., Mayfield, A., … & Engelman, J. A. (2021). Cancer Cell, 39(11), 1531-1547. 10.1016/j.ccell.2021.09.003
29. CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity. Teijeira, Á., Garasa, S., Gato, M., Alfaro, C., Migueliz, I., Cirella, A., … & Melero, I. (2020). Immunity, 52(5), 856-871. 10.1016/j.immuni.2020.03.001
30. Pirfenidone reduces immune-suppressive capacity of cancer-associated fibroblasts through targeting CCL17 and TNF-beta Aboulkheyr. Es, H., Zhand, S., Thiery, J. P., & Warkiani, M. E. (2020). Integrative Biology, 12(7), 188-197. 10.1093/intbio/zyaa014
31. Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids. Jenkins, R. W., Aref, A. R., Lizotte, P. H., Ivanova, E., Stinson, S., Zhou, C. W., … & Barbie, D. A. (2018).  Cancer discovery, 8(2), 196-215. 10.1158/2159-8290.CD-17-0833
32. Molecular Recalibration of PD-1+ Antigen-Specific T Cells from Blood and Liver. Otano, I., Escors, D., Schurich, A., Singh, H., Robertson, F., Davidson, B. R., … & Maini, M. K. (2018).  Molecular Therapy, 26(11), 2553-2566. 10.1016/j.ymthe.2018.08.013

3.1 Immune Checkpoint Modulation

1. Patient-derived organotypic tumor spheroids as a functional platform for predicting immunotherapeutic responses and guiding precision treatment for hepatocellular carcinoma. Song, F., Lu, Y.-J., Sun, H.-X., Cheng, J.-W., Li, W.-Z., Liu, Z.,…, & Yang, X.-R. (2026). Journal for ImmunoTherapy of Cancer, 14(5), e014555.
2. FAP-Targeted LTBR Agonist Drives HEV Differentiation and Immune Niche Formation for Improved Immunotherapy Response in Solid Tumours. Bianchi, R., Kunz, L., Hosse, R. J., Brydon, M., Amorim, A., Schwalie, P. C., … Umaña, P. (2026). Clinical Cancer Research.
3. Protocol for the preparation and analysis of patient-derived organotypic tumor spheroids. Palin, C. A., Jenkins, R. W., & Revach, O. Y. (2026). Protocol for the preparation and analysis of patient-derived organotypic tumor spheroids. STAR Protocols, 7(1), 104286.
4. E711-19 placement and orientation dictate CD8+ T cell response in structurally defined spherical nucleic acid vaccines. Hwang, J., Ocampo, T. A., Mayer, V., Kang, J., Paranandi, K. S., Kim, Y. J., … & Mirkin, C. A. (2026). Science Advances, 12(7), eaec3876
5. Use of patient-derived organotypic tumor spheroids for testing of viral vector gene therapy in combination with checkpoint blockade. Domingues, A. C. M., De Oliveira, S. B., Tessarollo, N. G., Lepique, A. P., Rodrigues, O., Sharova, T., … Strauss, B. E. (2025). Molecular Therapy Oncology, 33, 200942.
6. TBK1 Targeting Is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids. Sun, Y., Maggs, L., Panda, A., Wright, S. J., Cicerchia, A. M., Jenney, A., … & Jenkins, R. W. (2025). Cancer Immunology Research, 13(2), 210-228
7. Radiation-guided nanoparticles enhance the efficacy of PARP inhibitors in primary and metastatic BRCA1-deficient tumors via immunotherapy. Khoury, R., Longobardi, G., Barnatan, T. T., Venkert, D., Alvarado, A. G., Yona, A., … & Satchi-Fainaro, R. (2025). Journal of Controlled Release, 383, 113812
8. Immune targeting of triple-negative breast cancer through a clinically actionalbe STING agonist-CART cell platform. Zhang, Y., Li, Z., Ritter, J., Brea, E. J., Mahadevan, N. R., Dillon, D. A., … & Barbie, T. U. (2025). Cell Reports Medicine
9. RNA sensing induced by chromosome missegregation augments anti-tumor immunity. Sasaki, N., Homme, M., Murayama, T., Osaki, T., Tenma, T., An, T., … & Kitajima, S. (2025). Molecular cell, 85(4), 770-786
10. 205P Modelling of NSCLC aPD1 responses in bronchoscopc biopsies on chip (bronchoBOCs). Douka, K., Frantzi, M., Matthaiakaki-Panagiotaki, M., Mazzoni, F., Fancelli, S., Pilozzi, S., … & Tsoumakidou, M. (2023). Journal of Thoracic Oncology, 18(4), S151. 10.1016/S1556-0864(23)00458-6
11. EDIL3 as an Angiogenic Target of Immune Exclusion Following Checkpoint Blockade. Tabasum, S., Thapa, D., Giobbie-Hurder, A., Weirather, J. L., Campisi, M., Schol, P. J., … & Hodi, F. S. (2023).Cancer immunology research, 11(11), 1493-1507. 10.1158/2326-6066.CIR-23-0171
12. Targeting TBK1 to overcome resistance to cancer immunotherapy. Sun, Y., Revach, O. Y., Anderson, S., Kessler, E. A., Wolfe, C. H., Jenney, A., … & Jenkins, R. W. (2023). Nature, 615(7950), 158-167. 10.1038/s41586-023-05704-6
13. Translational Studies Using the MALT1 Inhibitor (S)-Mepazine to Induce Treg Fragility and Potentiate Immune Checkpoint Therapy in Cancer. Di Pilato, M., Gao, Y., Sun, Y., Fu, A., Grass, C., Seeholzer, T., … & Keller, P. (2023). ournal of Immunotherapy and Precision Oncology, 6(2), 61-73. 10.36401/JIPO-22-18
14. MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer. Kitajima, S., Tani, T., Springer, B. F., Campisi, M., Osaki, T., Haratani, K., … & Barbie, D. A. (2022). 40(10), 1128-1144
15. WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway. Guo, E., Xiao, R., Wu, Y., Lu, F., Liu, C., Yang, B., … & Chen, G. (2021). Journal of Experimental Medicine, 219(1), e20210789. 10.1084/jem.20210789
16. Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade. Sehgal, K., Portell, A., Ivanova, E. V., Lizotte, P. H., Mahadevan, N. R., Greene, J. R., … & Barbie, D. A. (2021). The Journal of clinical investigation, 131(2).  10.1172/JCI135038
17. Mesenchymal stem cells induce PD‐L1 expression through the secretion of CCL5 in breast cancer cells. Aboulkheyr Es, H., Bigdeli, B., Zhand, S., Aref, A. R., Thiery, J. P., & Warkiani, M. E. (2021). Journal of Cellular Physiology, 236(5), 3918-3928. 10.1002/jcp.30135
18. BRD4 Inhibition by AZD5153 Promotes Antitumor Immunity via Depolarizing M2 Macrophages. Li, X., Fu, Y., Yang, B., Guo, E., Wu, Y., Huang, J., … & Chen, G. (2020).Frontiers in Immunology, 11, 89. 10.3389/fimmu.2020.00089
19. CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity. Teijeira, Á., Garasa, S., Gato, M., Alfaro, C., Migueliz, I., Cirella, A., … & Melero, I. (2020). Immunity, 52(5), 856-871. 10.1016/j.immuni.2020.03.001
20. PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer. Diskin, B., Adam, S., Cassini, M. F., Sanchez, G., Liria, M., Aykut, B., … & Miller, G. (2020). Nature immunology, 21(4), 442-454. 10.1038/s41590-020-0620-x
21. Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade. Rashidian, M., LaFleur, M. W., Verschoor, V. L., Dongre, A., Zhang, Y., Nguyen, T. H., … & Ploegh, H. L. (2019). Proceedings of the National Academy of Sciences, 116(34), 16971-16980.  10.1073/pnas.1905005116
22. Innate αβ T cells mediate antitumor immunity by orchestrating immunogenic macrophage programming. Hundeyin, M., Kurz, E., Mishra, A., Rossi, J. A. K., Liudahl, S. M., Leis, K. R., … & Miller, G. (2019). Cancer discovery, 9(9), 1288-1305. 10.1158/2159-8290.CD-19-0161
23. Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer. Kitajima, S., Ivanova, E., Guo, S., Yoshida, R., Campisi, M., Sundararaman, S. K., … & Barbie, D. A. (2019). Cancer discovery, 9(1), 34-45.  10.1158/2159-8290.CD-18-0689
24. 3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade. Aref, A. R., Campisi, M., Ivanova, E., Portell, A., Larios, D., Piel, B. P., … & Jenkins, R. W. (2018).  Lab on a Chip, 18(20), 3129-3143. 10.1039/C8LC00322J
25. BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non–Small Cell Lung Cancer. Adeegbe, D. O., Liu, S., Hattersley, M. M., Bowden, M., Zhou, C. W., Li, S., … & Wong, K. K. (2018). Cancer immunology research, 6(10), 1234-1245. 10.1158/2326-6066.CIR-18-0077
26. CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation. Deng, J., Wang, E. S., Jenkins, R. W., Li, S., Dries, R., Yates, K., … & Wong, K. K. (2018). Cancer discovery, 8(2), 216-233. 10.1158/2159-8290.CD-17-0915
27. Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma. Sade-Feldman, M., Yizhak, K., Bjorgaard, S. L., Ray, J. P., de Boer, C. G., Jenkins, R. W., … & Hacohen, N. (2018). Cell, 175(4), 998-1013.  10.1016/j.cell.2018.10.038
28. Molecular Recalibration of PD-1+ Antigen-Specific T Cells from Blood and Liver. Otano, I., Escors, D., Schurich, A., Singh, H., Robertson, F., Davidson, B. R., … & Maini, M. K. (2018). Molecular Therapy, 26(11), 2553-2566. 10.1016/j.ymthe.2018.08.013
29. RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer. Wang, W., Marinis, J. M., Beal, A. M., Savadkar, S., Wu, Y., Khan, M., … & Miller, G. (2018). Cancer cell, 34(5), 757-774. 10.1016/j.ccell.2018.10.006
30. Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses. Cañadas, I., Thummalapalli, R., Kim, J. W., Kitajima, S., Jenkins, R. W., Christensen, C. L., … & Barbie, D. A. (2018).Nature medicine, 24(8), 1143-1150.  10.1038/s41591-018-0116-5

3.2 Immune Cell-Mediated Killing

1. Engineering “Off-the-Shelf” TCR-T Cells: A Transient mRNA Platform for Balanced Alloreactivity and Functionality. Shan, H., Yirong, D., Qi, C., Chia, A., Lim, J., Kit, H. S., … Tanoto Tan, A. (2026). Molecular Therapy Oncology.
2. CAR T cells secreting anti-EpCAM bispecific T cell engagers overcome tumor heterogeneity in targeting epithelial-originated carcinomas. Wang, B., Lee, W.-H., Hu, Y., Yeap, Y. Y. C., Ngoh, E. Z. X., Soh, M. K., … Wang, C.-I. (2026). Molecular Therapy.
3. PTPN2 inhibition unleashes response to STING agonism in head and neck squamous cell cancer. Li, Z., Fu, C., Sehgal, K., Egloff, A. M., Thai, T. C., Monge, O. A., … Barbie, D. A. (2026). (2026). Nature Communications.
4. Vascular STING activation facilitates NK cell anti-tumor immunity in small cell lung cancer. Campisi, M., Osaki, T., Dryg, I., Stornante, C., Wolff, J., Weirather, J., … & Mahadevan, N. R. (2026). Cancer Cell
5. E711-19 placement and orientation dictate CD8+ T cell response in structurally defined spherical nucleic acid vaccines. Hwang, J., Ocampo, T. A., Mayer, V., Kang, J., Paranandi, K. S., Kim, Y. J., … & Mirkin, C. A. (2026). Science Advances, 12(7), eaec3876
6. The impact of targeting TRAF2 and NCK-interacting protein kinase (TNIK) on anti-tumor effect and tumor immune environment in c-MYC-high small cell lung cancer. Tanimoto, A., Ramkumar, K., Stewart, C. A., Zhang, B., Concannon, K., Cardnell, R. J., … Byers, L. A. (2025). Journal of Thoracic Oncology, S1556086425030667.
7. Mesothelin is a surface antigen present on human meningioma and can be effectively targeted by CAR T-cells. Ramapriyan, R., Barker 2nd, F. G., Richardson, L. G., Sun, J., Vandecandelaere, G., Shim, J. M., … & Choi, B. D. (2025). Neuro-Oncology, noaf155
8. Immune targeting of triple-negative breast cancer through a clinically actionable STING agonist-CAR T cell platform. Zhang, Y., Li, Z., Ritter, J., Brea, E. J., Mahadevan, N. R., Dillon, D. A., … & Barbie, T. U. (2025). Cell Reports Medicine
9. Radiation-guided nanoparticles enhance the efficacy of PARP inhibitors in primary and metastatic BRCA1-deficient tumors via immunotherapy. Khoury, R., Longobardi, G., Barnatan, T. T., Venkert, D., Alvarado, A. G., Yona, A., … & Satchi-Fainaro, R. (2025). Journal of Controlled Release, 383, 113812
10. Patient-specific vascularized tumor model: Blocking monocyte recruitment with multispecific antibodies targeting CCR2 and CSF-1R. Nguyen, H. T., Kan, E. L., Humayun, M., Gurvich, N., Offeddu, G. S., Wan, Z., … & Kamm, R. D. (2025). Biomaterials, 312, 122731
11. TBK1 Targeting Is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids. Sun, Y., Maggs, L., Panda, A., Wright, S. J., Cicerchia, A. M., Jenney, A., … & Jenkins, R. W. (2025). Cancer Immunology Research, 13(2), 210-228
12. RNA sensing induced by chromosome missegregation augments anti-tumor immunity. Sasaki, N., Homme, M., Murayama, T., Osaki, T., Tenma, T., An, T., … & Kitajima, S. (2025). Molecular cell, 85(4), 770-786
13. In vitro integration of a functional vasculature to model endothelial regulation of chemotherapy and T-cell immunotherapy in liver cancer. Vasudevan, J., Vijayakumar, R., Reales-Calderon, J. A., Lam, M. S., Ow, J. R., Aw, J., … & Pavesi, A. (2025). Biomaterials, 123175
14. Pooled screening for CAR function identifies novel IL-13Rα2-targeted CARs for treatment of glioblastoma. Gordon, K. S., Perez, C. R., Garmilla, A., Lam, M. S., Aw, J. J., Datta, A., … & Birnbaum, M. E. (2025). Journal for Immunotherapy of Cancer, 13(1), e009574
15. Retina-on-chip: engineering functional in vitro models of the human retina using organ-on-chip technologyThe 3D organ-on-a-chip model unveils a dual role of GDF-15 in vascular growth. Oosten, E. M., & ávan der Meer, A. D. (2025). Lab on a Chip
16. Pericytes Promote More Vascularization than Stromal Cells via an Interleukin‐6‐Dependent Mechanism in Microfluidic Chips. Gonzalez‐Rubio, J., Kubiza, H., Xu, Y., Koenigs‐Werner, H., Schmitz, M. S., Schedel, M., … & Thiebes, A. L. (2025). Advanced Science, 2408131
17. CD19 CAR-expressing iPSC-derived NK cells effectively enhance migration and cytotoxicity into glioblastoma by targeting to the pericytes in tumor microenvironment. Kong, D., Kwon, D., Moon, B., Kim, D. H., Kim, M. J., Choi, J., & Kang, K. S. (2024). CBiomedicine & Pharmacotherapy, 174, 116436.  10.1016/j.biopha.2024.116436
18. G9a/GLP inhibition during ex vivo lymphocyte expansion increases in vivo cytotoxicity of engineered T cells against hepatocellular carcinoma. Lam, M. S., Reales-Calderon, J. A., Ow, J. R., Aw, J. J., Tan, D., Vijayakumar, R., … & Pavesi, A. (2023).  Nature Communications, 14(1), 563.  10.1038/s41467-023-36160-5
19. PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy. Zhang, D., Li, A. M., Hu, G., Huang, M., Yang, F., Zhang, L., … & Fan, Y. (2023). Cell metabolism, 35(3), 517-534.  10.1016/j.cmet.2023.01.010
20. Activation of Tumor-Cell STING Primes NK-Cell Therapy. Knelson, E. H., Ivanova, E. V., Tarannum, M., Campisi, M., Lizotte, P. H., Booker, M. A., … & Barbie, D. A. (2022). Cancer immunology research, 10(8), 947-961. 10.1158/2326-6066.CIR-22-0017
21. Direct imaging and automatic analysis in tumor-on-chip reveal cooperative antitumoral activity of immune cells and oncolytic vaccinia virus. Mencattini, A., Lansche, C., Veith, I., Erbs, P., Balloul, J. M., Quemeneur, E., … & Martinelli, E. (2022). Biosensors and Bioelectronics, 215, 114571. 10.1016/j.bios.2022.114571
22. Fibroblasts Impair Migration and Antitumor Activity of NK-92 Lymphocytes in a Melanoma-on-Chip Model. Iaia, I., Brancato, V., Caballero, D., Reis, R. L., Aglietta, M., Sangiolo, D., & Kundu, S. C. (2022). Bioengineering, 10(1), 52.  10.3390/bioengineering10010052
23. Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes. Sengupta, S., Das, S., Crespo, A. C., Cornel, A. M., Patel, A. G., Mahadevan, N. R., … & George, R. E. (2022). Nature cancer, 3(10), 1228-1246.  10.1038/s43018-022-00427-5
24. Boosting Natural Killer Cell Therapies in Glioblastoma Multiforme Using Supramolecular Cationic Inhibitors of Heat Shock Protein 90. Saha, T., van Vliet, A. A., Cui, C., Macias, J. J., Kulkarni, A., Pham, L. N., … & Goldman, A. (2021).Frontiers in Molecular Biosciences, 8, 754443. 10.3389/fmolb.2021.754443
25. Human MAIT cells endowed with HBV specificity are cytotoxic and migrate towards HBV-HCC while retaining antimicrobial functions. Healy, K., Pavesi, A., Parrot, T., Sobkowiak, M. J., Reinsbach, S. E., Davanian, H., … & Chen, M. S. (2021). JHEP Reports, 3(4), 100318.  10.1016/j.jhepr.2021.100318
26. IL-15 mediated expansion of rare durable memory T cells following adoptive cellular therapy. Kohli, K., Yao, L., Nowicki, T. S., Zhang, S., Black, R. G., Schroeder, B. A., … & Pollack, S. M. (2021). Journal for immunotherapy of cancer, 9(5).  10.1136/jitc-2020-002232
27. Immunosuppressive drug‐resistant armored T‐cell receptor T cells for immune therapy of HCC in liver transplant patients. Hafezi, M., Lin, M., Chia, A., Chua, A., Ho, Z. Z., Fam, R., … & Bertoletti, A. (2021). Hepatology, 74(1), 200-213. 10.1002/hep.31662
28. CRISPR-Mediated Base Conversion Allows Discriminatory Depletion of Endogenous T Cell Receptors for Enhanced Synthetic Immunity. Preece, R., Pavesi, A., Gkazi, S. A., Stegmann, K. A., Georgiadis, C., Tan, Z. M., … & Qasim, W. (2020). Molecular Therapy-Methods & Clinical Development, 19, 149-161. 10.1016/j.omtm.2020.09.002
29. CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity. Teijeira, Á., Garasa, S., Gato, M., Alfaro, C., Migueliz, I., Cirella, A., … & Melero, I. (2020). Immunity, 52(5), 856-871.  10.1016/j.immuni.2020.03.001
30. Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer. Kitajima, S., Ivanova, E., Guo, S., Yoshida, R., Campisi, M., Sundararaman, S. K., … & Barbie, D. A. (2019).Cancer discovery, 9(1), 34-45.  10.1158/2159-8290.CD-18-0689
31. Molecular Recalibration of PD-1+ Antigen-Specific T Cells from Blood and Liver. Otano, I., Escors, D., Schurich, A., Singh, H., Robertson, F., Davidson, B. R., … & Maini, M. K. (2018). Molecular Therapy, 26(11), 2553-2566. 10.1016/j.ymthe.2018.08.013
32. A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors. Pavesi, A., Tan, A. T., Koh, S., Chia, A., Colombo, M., Antonecchia, E., … & Bertoletti, A. (2017). JCI insight, 2(12). 10.1172/jci.insight.89762

4.1 Neurobiology

1. Subventricular Zone-on-a-Chip: A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage. Zamproni, L. N., Gökçe, B., Gram, M., Holliday, C., Sendemir, A., Porcionatto, M. A., & Herland, A. (2025). Advanced Science, e02145
2. ID1 high/activin A high glioblastoma cells contribute to resistance to anti-angiogenesis therapy through malformed vasculature. Choi, S. H., Jang, J., Kim, Y., Park, C. G., Lee, S. Y., Kim, H., & Kim, H. (2024). Cell Death & Disease, 15(4), 292
3. N-acetyltransferase 10 promotes glioblastoma malignancy via mRNA stabilization of Jumonji and AT-rich interaction domain containing 2. Inoki, T., Tsuruta, A., Masakado, Y., Kai, Y., Yoshida, Y., Matsunaga, N., … & Koyanagi, S. (2025). Journal of Biological Chemistry, 108544
4. Age-related meningeal extracellular matrix remodeling compromises CNS lymphatic function. Hitpass Romero, K., Stevenson, T. J., Smyth, L. C., Watkin, B., McCullough, S. J., Vinnell, L., … & Rustenhoven, J. (2025). Journal of Neuroinflammation, 22(1), 1-21
5. Pooled screening for CAR function identifies novel IL-13Rα2-targeted CARs for treatment of glioblastoma. Gordon, K. S., Perez, C. R., Garmilla, A., Lam, M. S., Aw, J. J., Datta, A., … & Birnbaum, M. E. (2025). Journal for Immunotherapy of Cancer, 13(1), e009574
6. Interactions of Neuronally Induced Stem Cells from Apical Papilla Spheres, Stems Cells from Apical Papilla, and Human Umbilical Vascular Endothelial Cells on Vasculogenesis and Neurogenesis. Basabrain, M. S., Zhong, J., Liu, J., Zhang, Y., Abdalla, M. M., & Zhang, C. (2024). Journal of Endodontics, 50(1), 64-73
7. Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage. Rustenhoven, J., Pavlou, G., Storck, S. E., Dykstra, T., Du, S., Wan, Z., … & Kipnis, J. (2023). Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage. Journal of Experimental Medicine, 220(7), e20221929
8. Bioengineered perfused human brain microvascular networks enhance neural progenitor cell survival, neurogenesis, and maturation. Winkelman, M. A., & Dai, G. (2023). Science Advances, 9(19), eaaz9499
9. Neuroregenerative potential of stem-cells-from-apical-papilla–derived neuronal cell spheroids regulated by stem cells from apical papillae under various microenvironments in a pulp-on-chip System. Luo, H., Basabrain, M. S., Zhong, J., Liu, J., Zhang, Y., Qi, Y., … & Zhang, C. (2022). Journal of Endodontics, 48(11), 1367-1377
10. Response of neuroglia to hypoxia-induced oxidative stress using enzymatically crosslinked hydrogels. Zambuto, S. G., Serrano, J. F., Vilbert, A. C., Lu, Y., Harley, B. A., & Pedron, S. (2020). MRS communications, 10(1), 83-90

4.2 Blood-Brain Barrier (BBB)

1. 3D Vessels-on-Chip using isogenic hiPSC-derived VSMCs reveal NOTCH3-driven alterations in brain small vessel disease. Cuenca, M. V., Tsikari, T., Cerfontaine, M. N., Gallant, J. L., van den Hil, F. E., Bouma, M. J., … & Orlova, V. V. (2026). Stem Cell Reports
2. Brain Pericytes and Wnt/β-Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC-Derived Model. Pinto, H. N., Kok, N. R., Hauger, P. C., Karsten-van Diepen, M., de Kok, M., Paauw, N. J., van der Pol, S. M. A., Nugteren-Boogaard, J. P., … & Helgo E. de Vries. (2026) Small Methods
3. A fully iPS-cell-derived 3D model of the human blood–brain barrier for exploring neurovascular disease mechanisms and therapeutic interventions. González-Gallego, J., Todorov-Völgyi, K., Müller, S. A., Antesberger, S., Todorov, M. I., Malik, R., … & Paquet, D. (2025). Nature Neuroscience, 1-14
4. Self-assembling 3D vessel-on-chip model with hiPSC-derived astrocytes. Nahon, D. M., Cuenca, M. V., van den Hil, F. E., Hu, M., de Korte, T., Frimat, J. P., … & Orlova, V. V. (2024). Stem Cell Reports, 19(7), 946-956
5. Bioengineered perfused human brain microvascular networks enhance neural progenitor cell survival, neurogenesis, and maturation. Winkelman, M. A., & Dai, G. (2023). Science Advances, 9(19), eaaz9499
6. Simultaneous induction of vasculature and neuronal network formation on a chip reveals a dynamic interrelationship between cell types. Isosaari, L., Vuorenpää, H., Yrjänäinen, A., Kapucu, F. E., Kelloniemi, M., Pakarinen, T. K., … & Narkilahti, S. (2023). Cell Communication and Signaling, 21(1), 132.  
7. Unveiling the Influence of Tumor Microenvironment and Spatial Heterogeneity on Temozolomide Resistance in Glioblastoma Using an Advanced Human In Vitro Model of the Blood‐Brain Barrier and Glioblastoma. Lam, M. S., Aw, J. J., Tan, D., Vijayakumar, R., Lim, H. Y. G., Yada, S., … & Pavesi, A. (2023). Small, 19(52), 2302280.  
8. Engineered human blood–brain barrier microfluidic model for vascular permeability analyses. Hajal, C., Offeddu, G. S., Shin, Y., Zhang, S., Morozova, O., Hickman, D., … & Kamm, R. D. (2022). Nature protocols, 17(1), 95-128. 
9. Interstitial flow enhances the formation, connectivity, and function of 3D brain microvascular networks generated within a microfluidic device. Winkelman, M. A., Kim, D. Y., Kakarla, S., Grath, A., Silvia, N., & Dai, G. (2022).Lab on a Chip, 22(1), 170-192
10. Study of the neurotoxicity of indoor airborne nanoparticles based on a 3D human blood-brain barrier chip. Li, Y., Liu, Y., Hu, C., Chang, Q., Deng, Q., Yang, X., & Wu, Y. (2020). Environment international, 143, 105598
11. Ex vivo dynamics of human glioblastoma cells in a microvasculature‐on‐a‐chip system correlates with tumor heterogeneity and subtypes. Xiao, Y., Kim, D., Dura, B., Zhang, K., Yan, R., Li, H., … & Fan, R. (2019). Advanced Science, 6(8), 1801531  
12. 3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes. Campisi, M., Shin, Y., Osaki, T., Hajal, C., Chiono, V., & Kamm, R. D. (2018). Biomaterials, 180, 117-129

1. 3D Vessels-on-Chip using isogenic hiPSC-derived VSMCs reveal NOTCH3-driven alterations in brain small vessel disease. Cuenca, M. V., Tsikari, T., Cerfontaine, M. N., Gallant, J. L., van den Hil, F. E., Bouma, M. J., … & Orlova, V. V. (2026). Stem Cell Reports
2. Subventricular Zone-on-a-Chip: A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage. Zamproni, L. N., Gökçe, B., Gram, M., Holliday, C., Sendemir, A., Porcionatto, M. A., & Herland, A. (2025). Advanced Science, e02145
3. Semaphorin-4D signaling in recruiting dental stem cells for vascular stabilization. Zhang, L., Thalakiriyawa, D. S., Liu, J., Yang, S., Wang, Y., & Dissanayaka, W. L. (2025). Stem Cell Research & Therapy, 16(1), 25
4. iPSC-derived mesenchymal stromal cells stimulate neovascularization less than their primary counterparts. Gonzalez-Rubio, J., Zeevaert, K., Buhl, E. M., Schedel, M., Jockenhoevel, S., Cornelissen, C. G., … & Thiebes, A. L. (2025). Life Sciences, 361, 123298
5. Gelatin maleimide microgels for hematopoietic progenitor cell encapsulation. Thompson, G. B., Gilchrist, A. E., Lam, V. M., Nunes, A. C., Payan, B. A., Mora‐Boza, A., … & Harley, B. A. (2024). Journal of Biomedical Materials Research Part A.  10.1002/jbm.a.37765
6. Combinational Treatment Involving Decellularized Extracellular Matrix Hydrogels With Mesenchymal Stem Cells Increased the Efficacy of Cell Therapy in Pancreatitis. Kojima, H., Kushige, H., Yagi, H., Nishijima, T., Moritoki, N., Nagoshi, N., … & Kitagawa, Y. (2023). Cell Transplantation, 32, 09636897231170437 10.1177/09636897231170437
7. Improvements in Maturity and Stability of 3D iPSC-Derived Hepatocyte-like Cell Cultures. Suominen, S., Hyypijev, T., Venäläinen, M., Yrjänäinen, A., Vuorenpää, H., Lehti-Polojärvi, M., … & Viiri, L. E. (2023). Cells, 12(19), 2368. 10.3390/cells12192368

5.2 Environmental Assessment

1. Two- and Three-Dimensional Culture Systems: Respiratory In Vitro Tissue Models for Chemical Screening and Risk-Based Decision Making. Wallace, J., McElroy, M. C., Klausner, M., Corley, R., & Ayehunie, S. (2025). Pharmaceuticals, 18(1), 113
2. Atmospheric nanoparticles affect vascular function using a 3D human vascularized organotypic chip. Li, Y., Wu, Y., Liu, Y., Deng, Q. H., Mak, M., & Yang, X. (2019).Nanoscale, 11(33), 15537-15549. 10.1039/C9NR03622A
3. Protein corona of airborne nanoscale PM2.5 induces aberrant proliferation of human lung fibroblasts based on a 3D organotypic culture. Li, Y., Wang, P., Hu, C., Wang, K., Chang, Q., Liu, L., … & Wu, Y. (2018). Scientific Reports, 8(1), 1939. 10.1038/s41598-018-20445-7
4. Functional human 3D microvascular networks on a chip to study the procoagulant effects of ambient fine particulate matter. Li, Y., Pi, Q. M., Wang, P. C., Liu, L. J., Han, Z. G., Shao, Y., … & Wu, Y. (2017). RSC Advances, 7(88), 56108-56116. 10.1039/C7RA11357A

5.3 Bone and Cartilage

1. Synthetic biodegradable microporous hydrogels for in vitro 3D culture of functional human bone cell networks. Zauchner, D., Müller, M. Z., Horrer, M., Bissig, L., Zhao, F., Fisch, P., … & Qin, X. H. (2024). Nature Communications, 15(1), 5027. 10.1038/s41467-024-49280-3
2. Modulation of inflammation by anti-TNF α mAb-dendrimer nanoparticles loaded in tyramine-modified gellan gum hydrogels in a cartilage-on-a-chip model.  Oliveira, I. M., Carvalho, M. R., Fernandes, D. C., Abreu, C. M., Maia, F. R., Pereira, H., … & Oliveira, J. M. (2021). Journal of Materials Chemistry B, 9(20), 4211-4218. 10.1039/D1TB00802A

5.4 Organoids

1. Vascularized and perfusable human Heart‐on‐a‐Chip model recapitulates aspects of myocardial ischemia and enables analysis of nanomedicine delivery. Kim, J., Zhang, X., Wang, R., Najer, A., Lau, Q. Y., Cammack‐Najera, A., … & Stevens, M. M. (2025). . Advanced Materials, e18909
2. Two- and Three-Dimensional Culture Systems: Respiratory In Vitro Tissue Models for Chemical Screening and Risk-Based Decision Making. Wallace, J., McElroy, M. C., Klausner, M., Corley, R., & Ayehunie, S. (2025). Pharmaceuticals, 18(1), 113
3. Retina-on-chip: engineering functional in vitro models of the human retina using organ-on-chip technologyThe 3D organ-on-a-chip model unveils a dual role of GDF-15 in vascular growth. Oosten, E. M., & ávan der Meer, A. D. (2025). Lab on a Chip
4. Semaphorin-4D signaling in recruiting dental stem cells for vascular stabilization. Zhang, L., Thalakiriyawa, D. S., Liu, J., Yang, S., Wang, Y., & Dissanayaka, W. L. (2025). Stem Cell Research & Therapy, 16(1), 25
5. Pericytes Promote More Vascularization than Stromal Cells via an Interleukin‐6‐Dependent Mechanism in Microfluidic Chips. Gonzalez‐Rubio, J., Kubiza, H., Xu, Y., Koenigs‐Werner, H., Schmitz, M. S., Schedel, M., … & Thiebes, A. L. (2025). Advanced Science, 2408131
6. Atmospheric nanoparticles affect vascular function using a 3D human vascularized organotypic chip. Li, Y., Wu, Y., Liu, Y., Deng, Q. H., Mak, M., & Yang, X. (2019).Nanoscale, 11(33), 15537-15549. 10.1039/C9NR03622A
7. Fluorescence‐Guided Spatial Drug Screening in 3D Colorectal Cancer Spheroids. Yau, J. N. N., Yempala, T., Muthuramalingam, R. P. K., Giustarini, G., Teng, G., Ang, W. H., … & Pastorin, G. (2024). Advanced Healthcare Materials, 2400203. 10.1002/adhm.202400203
8. Modulation of cell physiology by bispecific nanobodies enabling changes in the intracellular localization of organelle proteins. Tsuruta, A., Kanetani, D., Shiiba, Y., Inoki, T., Yoshida, Y., Matsunaga, N., … & Ohdo, S. (2023). Biochemical Pharmacology, 215, 115708. 10.1016/j.bcp.2023.115708
9. Modelling T-cell immunity against hepatitis C virus with liver organoids in a microfluidic coculture system. Natarajan, V., Simoneau, C. R., Erickson, A. L., Meyers, N. L., Baron, J. L., Cooper, S., … & Ott, M. (2022). Open Biology, 12(3), 210320.  10.1098/rsob.210320

 5.5 Liver Model

1. EMULSION human liver-on-a-chip for non-alcoholic steatohepatitis (NASH) drug testing. Balachander, G., Ng, I. C., Pai, R. R., Mitra, K., Tasnim, F., Lim, Y. S., … & Yu, H. (2025). Lab on a Chip

 5.6 Lymphatics Model

1. Utility of an in vitro lymphatics on-chip model for rank ordering subcutaneous absorption of monoclonal antibodies. Ledo, A. M., Misiewicz, G., Dimke, T., Tschantz, W. R., Handel, J., Pelis, R., … & Kamm, R. D. (2025). Lab on a Chip