Voices
New application note with AIM Biotech and Nikon: Confocal Imaging of in vitro BBB model using idenTx platform
AIM Biotech and Nikon Instruments have produced a new application note demonstrating a robust and cost-effective way to assess neurotherapeutic drug transport and neurovascular function of the human blood brain barrier (BBB) in vitro. The human cell tri-culture BBB...
Webinar: Scaling-up Organ-on-chip Assays for drug discovery with AIM Biotech 3D Tissue Culture Systems and the Opentrons OT-2
In case you missed it, check out our recent webinar with our friends at Opentrons. AIM Biotech’s Sei Hein Lim talks about how to scale-up drug discovery research using AIM’s organiX and idenTx 3D tissue culture platforms in conjunction with the Opentrons OT-2 lab...
Ex vivo culture of human biopsies with idenTx: leveraging the STING pathway to complement NK-cell therapy
In a recent publication in Cancer Immunology Research, a team led by scientists at Dana-Farber Cancer Institute and Brigham and Women’s Hospital used AIM Biotech’s idenTx drug discovery platform to demonstrate the therapeutic potential of STING (stimulator of...
AIM Biotech partners with Nikon to provide organ-on-a-chip imaging and analysis contract services for drug discovery
Nikon Corporation announced on Wednesday that AIM Biotech is one of the select organ-on-a-chip (OOAC) providers to support Nikon’s expanding global contract research services for drug discovery. This partnership is a result of collaborative efforts between Nikon...
How AIM Biotech is automating organ-on-a-chip drug discovery
AIM Biotech is using Opentrons's OT-2 lab robot to implement automated drug discovery on in vitro platforms that provide more predictive data and higher throughput.
Understanding PD-L1 expression in breast cancer with the idenTx chip
In this last article of the immune checkpoint series, we discuss how scientists used AIM Biotech’s Avatar technology to study when, how, and which cells express the PD-L1 immune protein in breast cancer. PD-L1 expression promotes tumor growth by offering an...
Leveraging AIM’s BioAvatar technology to tackle previously-unknown effects of immune protein ligands in tumors
Although immune checkpoint protein PD-1 activation is known to participate in tumor development and to inhibit adoptive T cell therapy effects, the expression of its ligand PD-L1 during oncogenesis progression is not well understood. A group of scientists studied...
New application note with AIM Biotech and Nikon: Evaluating CAR-T cell dynamics in a 3D tumor microenvironment using confocal imaging
AIM Biotech and Nikon Instruments have produced a new application note demonstrating one way to more easily study the immune effects of Chimeric Antigen Receptor T (CAR-T) by combining AIM's three-dimensional idenTx cell assays with confocal imaging technology....
Simplify and isolate: A case study on how idenTx streamlines preclinical research
For today’s post in our immune checkpoint series, we’ll discuss work published in Cell in 2018 by Sade-Feldman et al., and how they leveraged the economy of cost from AIM’s idenTx organ-on-a-chip assays to turn what would have been a six-variable animal study into...
Step-by-step: Data and insights from a human cancer-on-a-chip model
Having a human cell-based model that mimics the in vivo tumor microenvironment and cell-to-cell interactions is invaluable for studying new cancer therapies. In our last post, we talked about growing spheroids using our idenTx family of 3D tissue culture chips and...
Modeling immune checkpoint blockade using idenTx
One of the major challenges in developing successful cancer therapies is the inhibitory effect caused by immune checkpoint resistance, normally including the PD-1 checkpoint protein in T cells that we’ve highlighted in previous posts. As a result, in vitro models...
Featured study: Building a new way to emulate the pancreatic tumor microenvironment for immunotherapy
Our friends at PavesiLab have published in Biomaterials Science about their new pancreatic tumor microenviornment model. See how they used AIM's idenTx chips to power their study.
