Simplify and isolate: A case study on how idenTx streamlines preclinical research
For today’s post in our immune checkpoint series, we’ll discuss work published in Cell in 2018 by Sade-Feldman et al., and how they leveraged the economy of cost from AIM’s idenTx organ-on-a-chip assays to turn what would have been a six-variable animal study into a...
Step-by-step: Data and insights from a human cancer-on-a-chip model
Having a human cell-based model that mimics the in vivo tumor microenvironment and cell-to-cell interactions is invaluable for studying new cancer therapies. In our last post, we talked about growing spheroids using our idenTx family of 3D tissue culture chips and...
Modeling immune checkpoint blockade using idenTx
One of the major challenges in developing successful cancer therapies is the inhibitory effect caused by immune checkpoint resistance, normally including the PD-1 checkpoint protein in T cells that we’ve highlighted in previous posts. As a result, in vitro models that...
Featured study: Building a new way to emulate the pancreatic tumor microenvironment for immunotherapy
The challenge To obtain significant results when studying cancer therapies, mimicking the human tumor microenvironment is critical if any such results are to be extrapolated to human treatments. In particular, pancreatic tumors present a challenge not readily met by...