Vasculogenesis

AngioPrime and VasQ Kit by AIM Biotech

Introducing Cell Systems: AngioPrime and VasQ Kit!

Reproducible, human-relevant models for predictive drug testing through the integration of standardized cell sources with AIM Biotech's MPS technology.

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Vasculogenesis Split
48 hour time lapse video of vascular network formation
Vasculogenesis Gradient

A 3D projected confocal image of a HUVEC microvascular network in an idenTx  chip. Stained with Hoechst for cell nuclei, and with Alexa-fluo-488 for VE-cadherin.

etaluma
Epifluorescence image of a HUVEC microvascular network, captured with Etaluma LS720. Blind deconvolution on z-stack of 43 images using Microvolution
Vasculogenesis Particle Flow
Particles flowing into a perfusable microvascular network

Protocol

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Key References

  1. Semaphorin-4D signaling in recruiting dental stem cells for vascular stabilization. Zhang, L., Thalakiriyawa, D. S., Liu, J., Yang, S., Wang, Y., & Dissanayaka, W. L. (2025). Stem Cell Research & Therapy, 16(1), 25
  2. iPSC-derived mesenchymal stromal cells stimulate neovascularization less than their primary counterparts. Gonzalez-Rubio, J., Zeevaert, K., Buhl, E. M., Schedel, M., Jockenhoevel, S., Cornelissen, C. G., … & Thiebes, A. L. (2025). Life Sciences, 361, 123298
  3. Pericytes Promote More Vascularization than Stromal Cells via an Interleukin‐6‐Dependent Mechanism in Microfluidic Chips. Gonzalez‐Rubio, J., Kubiza, H., Xu, Y., Koenigs‐Werner, H., Schmitz, M. S., Schedel, M., … & Thiebes, A. L. (2025). Advanced Science, 2408131
  4. Engineering polystyrene microtube-embedded composite hydrogels for tunable vascular morphogenesis. Li, X., Khan, S., Wang, L., Chen, Y., Fang, X., Zhou, Y., & Wang, Y. (2025). Biomedical Materials
  5. EMULSION human liver-on-a-chip for non-alcoholic steatohepatitis (NASH) drug testing. Balachander, G., Ng, I. C., Pai, R. R., Mitra, K., Tasnim, F., Lim, Y. S., … & Yu, H. (2025). Lab on a Chip
  6. Microphysiological Endothelial Models to Characterize Subcutaneous Drug Absorption. Offeddu, G. S., Serrano, J. C., Wan, Z., Bryniarski, M. A., Humphreys, S. C., Chen, S. W., … & Kamm, R. D. (2023). ALTEX-Alternatives to animal experimentation, 40(2), 299-313
  7. In vitro integration of a functional vasculature to model endothelial regulation of chemotherapy and T-cell immunotherapy in liver cancer. Vasudevan, J., Vijayakumar, R., Reales-Calderon, J. A., Lam, M. S., Ow, J. R., Aw, J., … & Pavesi, A. (2025). Biomaterials, 123175
  8. Retina-on-chip: engineering functional in vitro models of the human retina using organ-on-chip technology. Oosten, E. M., & ávan der Meer, A. D. (2025). Lab on a Chip
  9. Modeling early pathophysiological phenotypes of diabetic retinopathy in a human inner blood-retinal barrier-on-a-chip. Maurissen, T. L., Spielmann, A. J., Schellenberg, G., Bickle, M., Vieira, J. R., Lai, S. Y., … & Ragelle, H. (2024).  Nature Communications, 15(1), 1372
  10. Self-assembling 3D vessel-on-chip model with hiPSC-derived astrocytes. Nahon, D. M., Cuenca, M. V., van den Hil, F. E., Hu, M., de Korte, T., Frimat, J. P., … & Orlova, V. V. (2024).  Stem Cell Reports

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