Angiogenesis
Introducing Cell Systems: AngioPrime and VasQ Kit!
Reproducible, human-relevant models for predictive drug testing through the integration of standardized cell sources with AIM Biotech's MPS technology.
AIM 3D Cell Culture Chips offer a new perspective in studying angiogenesis by allowing the growth of new vascular sprouts in a 3D matrix from a pre-existing endothelial monolayer. With the transparent laminate at the bottom, the dynamic process of angiogenesis can be monitored in detail from a viewing angle that is perpendicular to the direction of sprouting. The two-media- channel design not only enables the generation of concentration gradient of angiogenic stimuli but also the application of interstitial flow that is very useful in inducing angiogenesis. This protocol covers the techniques to obtain consistent angiogenic sprouting in AIM chips.
Protocol
Share Protocols
Users can submit their protocols to be referenced in this section and given due credit.
Key References
- iPSC-derived mesenchymal stromal cells stimulate neovascularization less than their primary counterparts. Gonzalez-Rubio, J., Zeevaert, K., Buhl, E. M., Schedel, M., Jockenhoevel, S., Cornelissen, C. G., … & Thiebes, A. L. (2025). Life Sciences, 361, 123298
- Vascularized and Perfusable Human Heart‐on‐a‐Chip Model Recapitulates Aspects of Myocardial Ischemia and Enables Analysis of Nanomedicine Delivery. Kim, J., Zhang, X., Wang, R., Najer, A., Lau, Q. Y., Cammack‐Najera, A., … & Stevens, M. M. (2025). . Advanced Materials, e18909
- Engineering polystyrene microtube-embedded composite hydrogels for tunable vascular morphogenesis. Li, X., Khan, S., Wang, L., Chen, Y., Fang, X., Zhou, Y., & Wang, Y. (2025). Biomedical Materials
- The FKBPL-based therapeutic peptide, AD-01, protects the endothelium from hypoxia-induced damage by stabilising hypoxia inducible factor-α and inflammation. Ghorbanpour, S., Cartland, S. P., Chen, H., Seth, S., Ecker, R. C., Richards, C., … & McClements, L. (2025). Journal of Translational Medicine, 23(1), 309
- Retina-on-chip: engineering functional in vitro models of the human retina using organ-on-chip technology. Oosten, E. M., & ávan der Meer, A. D. (2025). Lab on a Chip
- Pericytes Promote More Vascularization than Stromal Cells via an Interleukin‐6‐Dependent Mechanism in Microfluidic Chips. Gonzalez‐Rubio, J., Kubiza, H., Xu, Y., Koenigs‐Werner, H., Schmitz, M. S., Schedel, M., … & Thiebes, A. L. (2025). Advanced Science, 2408131
- Patient-specific vascularized tumor model: Blocking monocyte recruitment with multispecific antibodies targeting CCR2 and CSF-1R. Nguyen, H. T., Kan, E. L., Humayun, M., Gurvich, N., Offeddu, G. S., Wan, Z., … & Kamm, R. D. (2025). Biomaterials, 312, 122731
- Neovascularization directed by CAVIN1/CCBE1/VEGFC confers TMZ-resistance in glioblastoma. Wang, M., Xia, D., Xu, D., Yin, Y., Xu, F., Zhang, B., … & Zou, J. (2024). Cancer Letters, 582, 216593
- The 3D organ-on-a-chip model unveils a dual role of GDF-15 in vascular growth. Sarad, K., Dulak, J., & Jaźwa-Kusior, A. (2024). Biochemical and Biophysical Research Communications, 733, 150441
- A placenta-on-a-chip model to determine the regulation of FKBPL and galectin-3 in preeclampsia. Ghorbanpour, S. M., Richards, C., Pienaar, D., Sesperez, K., Aboulkheyr Es, H., Nikolic, V. N., … & McClements, L. (2023). Cellular and Molecular Life Sciences, 80(2), 44
All publications related to Angiogenesis, can be found here.
Users can submit their publications to be referenced in this section.