Applications

Applications

Run simple assays or create complex biological models.

T Cell Efficiency Assay

Immune Cell-Mediated Killing

Functional assay for determining the killing efficiency of engineered T cells.
Immune Checkpoint Modulation

Immune Checkpoint Modulation

Ex vivo model recapitulating the immune checkpoint response, with tissue from syngeneic mice, PDX and clinical biopsies.
Extravasation

Extravasation

Intravasation & extravasation assays, together with spheroid dispersion assays, model the key steps in metastasis.
Cell Invasion

Cell Invasion

Cell migration/invasion assay that offers an unambiguous starting line, real-time imaging and the ability to engineer the microenvironment being invaded.
Vasculogenesis

Vasculogenesis

Perfusable microvascular networks to model target organs for metastasis assays, and for vascularising tutors/organoids.
Angiogenesis

Angiogenesis

Angiogenesis model for research and drug development.
Spheroid Dispersion

Spheroid Dispersion

Tumor spheroids co-cultured with endothelial cells model the epithelial-mesenchymal transition in cancer.
Blood Brain Barrier

Blood-Brain Barrier Model

Blood-brain barrier model comprising all-human cell triculture shows permeability level similar to in vivo models.

Protocols

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General Protocols

  • Learn the basics of using 3D cell culture chips and accessories.
  • These building blocks enable users to design their own organotypic models.
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Application-Specific Protocols

  • Use AIM chips & accessories to investigate vascular functions, cancer, neural guidance and stem cell differentiation.
  • Develop new models with your own combinations of cells and culture conditions.