Applications
Applications
Run simple assays or create complex biological models.
Immune Cell-Mediated Killing
Functional assay for determining the killing efficiency of engineered T cells.
Immune Checkpoint Modulation
Ex vivo model recapitulating the immune checkpoint response, with tissue from syngeneic mice, PDX and clinical biopsies.
Extravasation
Intravasation & extravasation assays, together with spheroid dispersion assays, model the key steps in metastasis.
Cell Invasion
Cell migration/invasion assay that offers an unambiguous starting line, real-time imaging and the ability to engineer the microenvironment being invaded.
Vasculogenesis
Perfusable microvascular networks to model target organs for metastasis assays, and for vascularising tutors/organoids.
Angiogenesis
Angiogenesis model for research and drug development.
Spheroid Dispersion
Tumor spheroids co-cultured with endothelial cells model the epithelial-mesenchymal transition in cancer.
Blood-Brain Barrier Model
Blood-brain barrier model comprising all-human cell triculture shows permeability level similar to in vivo models.
Protocols
General Protocols
- Learn the basics of using 3D cell culture chips and accessories.
- These building blocks enable users to design their own organotypic models.
Application-Specific Protocols
- Use AIM chips & accessories to investigate vascular functions, cancer, neural guidance and stem cell differentiation.
- Develop new models with your own combinations of cells and culture conditions.